This is a dietary supplement combination recommendation.

This combination helps improve your mood, soothe emotions, improve sleep, and also helps to alleviate negative emotions and repair cognitive impairments.

一、S001:Perlonfo® NAD+ Cellular Renewal Complex

This dietary supplement consists of β-nicotinamide mononucleotide (NMN), β-nicotinamide ribose (NR), anhydrous betaine (TMG), pyrroloquinoline quinone disodium salt (PQQ), and coenzyme Q10. It ensures cellular energy supply, regulates neurotransmitter balance, resists chronic damage, restores brain vitality, alleviates fatigue, and stabilizes your mood, leaving you free from anxiety.

reference

1.Canto,C. Menzies, K.J.Auwerx, J.NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus.Cell Metab. 2015; 22:31-53

reference link:NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Ramasarma T. A touch of history and a peep into the future of the lipid-quinone known as coenzyme Q and ubiquinone. Curr Sci.2012;102(10):1459–1471.

reference link: A touch of history and a peep into the future of the lipid-quinone known as coenzyme Q and ubiquinone on JSTOR

2.Pyrroloquinoline Quinone Stimulates MitochondrialBiogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1 Expression

reference link: Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression* - Journal of Biological Chemistry

3.Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention

Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and lipotoxicity). PQQ is novel among biofactors that are not currently accepted as vitamins or conditional vitamins. For example, the absence of PQQ in diets produces a response like a vitamin-related deficiency with recovery upon PQQ repletion in a dose-dependent manner. Moreover, potential health benefits, such as improved metabolic flexibility and immuno-and neuroprotection, are associated with PQQ supplementation. Here, we address PQQ’s role as an enzymatic cofactor or accessory factor and highlight mechanisms underlying PQQ’s actions. We review both large scale and targeted datasets demonstrating that a neonatal or perinatal PQQ deficiency reduces mitochondria content and mitochondrial-related gene expression. Data are reviewed that suggest PQQ’s modulation of lactate acid and perhaps other dehydrogenases enhance NAD+-dependent sirtuin activity, along with the sirtuin targets, such as PGC-1α, NRF-1, NRF-2 and TFAM; thus, mediating mitochondrial functions. Taken together, current observations suggest vitamin-like PQQ has strong potential as a potent therapeutic nutraceutical.

reference link: Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention

二、S003:Perlonfo® NeuroGuard Omega-3 + Ginkgo Complex

This dietary supplement consists of panaxsaponin aglycone and polygonatum odoratum extract. Panaxsaponin aglycone is the core substance through which ginsenosides exert their ultimate effect in the body. The product utilizes pharmaceutical-grade high-purity monomer components, supplemented by polygonatum odoratum to achieve complementary and synergistic effects, thereby exerting excellent efficacy in stabilizing mood.The classic combination of ginseng and jade bamboo reflects the therapeutic wisdom of traditional Chinese medicine, emphasizing the mutual complementarity of yin and yang and the nourishing of qi and yin. It possesses the functions of strengthening the body's foundation, dispelling pathogenic factors, calming the nerves, and improving intelligence. Modern research has confirmed that this nutrient has overall advantages in multi-target synergism, enhancement, and attenuation of toxicity: it can effectively regulate the levels of serotonin (5-HT) and dopamine (DA) in the brain to stabilize emotions. The Perlonfo dietary supplement can further alleviate neuroinflammation and repair damaged hippocampal neurons by inhibiting key pro-inflammatory factors such as NF-κB, repairing cell membranes, and improving cellular energy supply. This "internal and external repair" approach not only significantly improves negative depressive emotions but also has excellent protective and repair effects on concomitant cognitive impairment.

Reference

1.(S)-Protopanaxadiol Alleviates DRP1-Mediated Mitochondrial Dysfunction in a Depressive Model In Vitro and In Vivo via the SIRT1/PGC-1α Signaling Pathway

Depression is a complex and common mental illness affecting physical and psychological health. Panax ginseng C. A. Mey is a traditional Chinese medicine with abundant pharmacological activity and applications in regulating mood disorders. 20 (S)-Protopanaxadiol is the major intestinal metabolite of ginsenoside and one of the active components in ginseng. 20 (S)-Protopanaxadiol may exert neuroprotective and antidepressant effects by attenuating DRP1-mediated mitochondrial dysfunction and apoptosis by modulating the SIRT1/PGC-1α signaling pathway.

Reference link:https://www.mdpi.com/1420-3049/29/21/5085

2.Antidepressant‐like effects of 20(S)‐protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms

20(S)‐Protopanaxadiol (PPD) is a basic aglycone of the dammarane triterpenoid saponins and exerts antidepressant‐like effects on behaviour in the forced swimming test (FST) and tail suspension test (TST) and in rat olfactory bulbectomy depression models.

Reference link:  https://doi.org/10.1002/ptr.6446

三、S006:Perlonfo® NeuroGuard Omega-3 + Ginkgo Complex

This dietary supplement consists of Omega-3 (DHA and EPA) and ginkgo leaf extract. It follows the AHA-recommended golden ratio of DHA/EPA 2:1 for brain health, supplemented with pharmaceutical-grade ginkgo leaf extract, to establish a dual-targeting mechanism of "neurological repair + vascular optimization": Omega-3 is responsible for repairing damaged brain cells, regulating the HPA axis, and optimizing mitochondrial function, thereby improving emotional stability from the underlying level; ginkgo leaf directly enhances antidepressant efficacy by dilating cerebral blood vessels, increasing blood flow, and promoting serotonin synthesis. The synergistic effect of the two can effectively alleviate depressive symptoms and significantly improve cognitive function.

 reference

1.International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder

Patients with MDD usually require maintenance treatment after the acute depressive episode. However, we identified no studies having enough follow-up duration to address the prevention effects for recurrent MDD.Therefore, current evidence is not adequate to either support or refute the prescription of n–3 PUFAs as longerterm maintenance therapy or for recurrent major depressive episodes. However, considering that most antidepressant medication might be associated with higher dropout rates as compared to placebo, the advantage of tolerability profiles of n–3 PUFAs might suggest its potential in maintenance treatment (level 2).

reference link: DOI: https://doi.org/10.1159/000502652

2.Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) operate via pleiotropic mechanisms of action, and some of these mechanisms have the potential to improve depressive symptoms. These mechanisms include beneficial effects on anti-inflammatory and proresolving activities, the endocannabinoid system, the hypothalamic-pituitaryadrenal axis, neuroplasticity, glymphatic system function,and modulation of neurotransmitter systems.

reference link: DOI: 10.1097/MCO.0000000000001077 

3.reference link: DHA, EPA and their combination at various ratios differently modulated Aβ25-35-induced neurotoxicity in SH-SY5Y cells - Prostaglandins, Leukotrienes and Essential Fatty Acids

DHA, EPA and their combination at various ratios differently modulated Aβ25-35-induced neurotoxicity in SH-SY5Y cells.

the results from the present study have, for the first time demonstrated that 1) both DHA and EPA attenuate neuron apoptosis and improve cell viability, while pure DHA or DHA at higher ratio are better than EPA in the protection of cell viability; 2) DHA and EPA have synergistic anti-inflammatory effects in the AD model; 3) pure EPA or EPA at higher ratio are more effective in anti-oxidative stress, while pure DHA or DHA at higher ratio are more powerful than EPA for improving neurotrophic systems.

reference link: DHA, EPA and their combination at various ratios differently modulated Aβ25-35-induced neurotoxicity in SH-SY5Y cells - Prostaglandins, Leukotrienes and Essential Fatty Acids

4.The role of fatty acids in the emotional well-being of young adults:associations between fatty acid levelsand symptoms of depression, anxiety,stress, and sleep disturbances

reference link: DOI: https://doi.org/10.5114/ppn.2024.144224